ABSTRACT
AIM: Visceral hypersensitivity characterizes the irritable bowel syndrome (IBS). We evaluated the effect of a cold pressor test (CPT)--hand immersion in ice water for 1 minute, which evokes a sympathetic response--on rectosigmoid motility in patients with IBS and normal volunteers. Since many Indian patients with IBS complain of worsening of symptoms following a spicy meal, we also evaluated whether a high-chilli diet affects symptoms or changes rectosigmoid motility. METHODS: Fifteen men with IBS and 13 normal volunteers (all men) were studied. Baseline rectosigmoid manometry was done for 2 h, i.e., 1 h pre- and 1 h post-CPT. The subjects were then kept in hospital on a regular diet (approximately 5 g chilli daily) for 3 days, following which symptoms were reassessed and manometry repeated for 1 h. This was followed by a high-chilli diet (approximately 15 g/day) for 3 days, after which symptoms were reassessed and manometry repeated for 1 h. RESULTS: There was no difference in the baseline study in the pre-CPT period between patients and control subjects. CPT did not change rectosigmoid motility in either group. IBS patients had varied effect on symptoms but no change in rectosigmoid motility after the high-chilli diet. In the normal volunteers, there was increased activity in the low rectum after the high-chilli diet. CONCLUSIONS: Cold pressor test does not affect rectosigmoid motility in patients with IBS or normal subjects. A high-chilli diet has varied effect on symptoms in patients with IBS and does not affect rectosigmoid motility.
Subject(s)
Adult , Capsaicin/adverse effects , Cold Temperature/diagnosis , Colon, Sigmoid/physiology , Colonic Diseases, Functional/diagnosis , Diet/adverse effects , Gastrointestinal Motility/physiology , Humans , Male , Manometry , Middle Aged , Pressure , Rectum/physiology , Reference Values , Sensitivity and Specificity , Spices/adverse effectsABSTRACT
En México el consumo de chile constituye una tradición cultural y a sus efectos sobre la salud se les han atribuido, empíricamente, características controvertidas. En este trabajo se describen las creencias sobre el consumo de chile y la salud, en dos grupos de residentes de la Ciudad de México. Los resultados ratifican, por una parte, la gran variedad de efectos benéficos y/o nocivos que se asocian al consumo de este alimento y, por la otra, demuestran que los niveles de consumo no están relacionados con las creencias que se tienen en cuanto a su impacto en la salud
Eating chili peppers is a cultural tradition in Mexico. Controversial characteristics have been empirically associated to chili pepper consumption and human health. In this paper, the beliefs about the health impacts of chili pepper consumption in two independent groups of Mexico City residents are described. The results confirm, on the one hand, that there is a wide variety of health benefits and damages associated with chili pepper consumption, but on the other hand, that the levels of chili pepper consumption are not related to beliefs about its human health impact.
Subject(s)
Humans , Male , Female , Adult , Middle Aged , Capsicum/adverse effects , Capsaicin/adverse effects , Attitude to Health , Mexico , Feeding Behavior , Urban PopulationABSTRACT
OBJECTIVE: To explore the role of prostaglandins in protecting against chilli-induced early gastric vascular damage. METHODS: Early gastric vascular damage was induced in rats by oral administration of 8 mg/Kg chilli extract. The damage was assessed by estimating spectrophotometrically the amount of Evan's blue leaking into gastric tissue and luminal contents 10 min after exposure to chilli. Further groups of rats were pretreated with misoprostol (10, 25 or 50 micrograms/Kg) or dazmegrel (1, 5 or 25 mg) to evaluate their protective effects. RESULTS: Both misoprostol and dazmegrel were able to reduce gastric vascular damage induced by chilli in a dose-dependent fashion. CONCLUSION: Prostaglandins may play a role in protecting against chilli-induced early gastric vascular damage.